Propantheline
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It has been the most popular anti-cholinergic used for peptic ulcer. The higher ganglion blocking activity is believed to aid anti secretory effects & it relieves pain by anti spasmodic action also.
INDICATIONS: Peptic ulcer, gastritis, colitis.
DOSAGE: Peptic ulcer: 15 mg, 3 times daily before meals & 30 mg at night.
Other indications: 15 mg 2-3 times daily.
CONTRA-INDICATIONS: Obstructive disease of G-I tract & intestinal, urinary atony, pregnancy, glaucoma, Myasthenia gravis. Toxic megacolon in ulcerative colitis. Hiatus hernia associated with reflux oesophagitis.
SPECIAL PRECAUTIONS: Pyloric stenosis & where tachycardia is undesirable, severe cardiac disease. Renal or hepatic disease.
Paediatrics: Not recommended.
Pregnancy: Contraindicated.
Lactation: Use with caution.
Elederly: Reduced dose necessary.
DRUG INTERACTIONS: Anticholinergic effect with tricyclic antidepressants, phenothiazines, disopyramide, delayed gastric emptying causes delayed absorption of other drugs.