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It is capable of correcting abnormal motility throughout the GI tract. Cisapride appears to be devoid of dopaminergic blocking activity & it does not influence the concentration of prolactin in plasma or cause extrapyramidal symptoms.
INDICATIONS: Non-ulcer dyspepsia: Treatment of symptoms such as epigastric pain, early satiety, bloating, where organic disease has been excluded. Gastro-oesophageal reflux disease: treatment of symptoms such as epigastric pain, early satiety, anorexia, bloating & nausea associated with delayed gastric emptying secondary to systemic sclerosis and autonomic neuropathy of diabetes-origin. Chronic constipation.
CONTRA-INDICATIONS: Pregnancy. Patients in whom G.I. stimulation might be dangerous e.g. G.I. haemorrhage, mechnical obstruction or perforation.
SPEICAL PREACUTIONS: Breast feeding, impaired hepatic function. Sedative effects of benzodiazepines and alcohol may be acclerated.
SIDE-EFFECTS: Abdominal cramps, borborygmi and loose stools (diarrhea). Hedache, light headeness. Convulsions & extra pyramidal effects.
DRUG INTERACTIONS: Increase the rate of absorption an maximum concentration of co administered drugs like Diazepam. Enhances sedactive effects of Benzodiazepine and alcohol. Prothrombin time in patients on anticoagulants may be increased. Effects antagonized by anti cholinergic drugs.