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Lansoprazolle Is Also A Gastirc Proton Pump Inhibitors And Has Quicker
Penetration Through The Parietal Cell Membrane. It Hbinds To 3 Sites
On The H+K+ At Pase In The Parietal Cell There By Inhibits The Final
Stage Of Gastric Acid Formation Increspective Of The Stimulus. Lansoprazole
Has A 30% Greater Bioavailbility And Higher Lipophilicity Than Omeprazole.
Lansoprazole Increases Mucosal Oxygenation And Also Ncreases Secreation
Of Bicarbonate Ions. This Further Helps To Protect The Gastric Mucous
From Injury. Lansoprazole Should Be Taken In The Morning Before
Food.
Indications: Duodenal & Gastric Ulcers,
Reflux Oesophagitis, Zollinger-Ellison Syndrome.
Contraindications: Hypersensitivity.
Safety Profile: Prolonged Use.Possibilivility
Of Malignancy Should Be Exclude.
Adverse Effects: Nausea, Vomiting, Dyspepsia,
Constipation, Diarrhoea, Skin Rash, Dry Mouth, Arthralgia, Depression,
Peripheral Oedema, Headache, Urticaria And Pruitus.
Drug Interactions: Theophylline, Warfarin, Phenytoin,
Oral Contraceptives And Co-Adminstration With Sucralfate.
Dosage: 30 Mg Once Daily One Hour Prior To Meals.