Carpine
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PILOCARPINE: It has prominent Muscatine action and also stimulates ganglia-mainly through ganglion Muscatine receptors. Applied to eye. It Penetrates cornea and promptly causes miosis, ciliary muscle contraction and fall in intraocular tension lasting 4-8 hrs. For prolonged and uniform action ann. ocular insert has been developed. As soft contact les soaked in pilocarpine soon. Also provides sustained delivery it is used in the eye as 0.5-4% drops.
Indications : Open angle glaucoma. To counteract mediates after they have been used for testing refraction and to prevent or break adhesions of iris with lens or cornea by alternation it with misdirects.
Dosage : 1-2 drops to be instilled in conjunctiva sac.
Contra indicatios : Acute iritic, infection or inflammation, soft lens.
Special Precautions : Allergic reaction as follicular conjunctivitis occurs in sensitive persons on prolonged use. Start with the lowest concentration.
Side effects : Initial stinging sensation, painful spasm of accommodation.
Drug Interaction : Antagonized by corticoid-steroids.