Glyciphage
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It is a biguanide derivative. It delays absorption of glucose
from GI tract, increases insulin sensitivity and 2decreases hepatic
gluconeogensis.
INDICATIONS: Type II diabetes mellitus (NIDDM)
& secondary failure sulfonylureas.
CONTRAINDICATIONS: Insulin dependent diabetes
mellitus, ketoacidosis, severe stress trauma, CHF, pregnancy and
lactation.
SAFETY PROFILE: Chronic alcoholism, hepatic
and/or renal impairment, starvation.
ADVERSE EFFECTS: G.I. disturbances, lactic acidosis
and development of tolerance.
DRUG INTERACTIONS: Anticoagulants increase to
hypoglycaemic effect.
DOSAGE: 25 mg four times a day can be increased
to a maximum dose of 300 mg daily depending upon the levels of
blood glucose.