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DORYX (doxycycline hyclate) Delayed-Release Tablets, for oral administration, contain specially coated pellets of doxycycline hyclate, a broad-spectrum antibiotic synthetically derived from oxytetracycline, in a delayed-release formulation for oral administration.

INDICATIONS

To reduce the development of drug-resistant bacteria and maintain the effectiveness of DORYX and other antibacterial drugs, DORYX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

CONTRAINDICATIONS: SLE, porphyria and hypersensitivity.

SAFETY PROFILE : Not to use in pregnancy and children below the age of 8 years unused supplies of the antibiotic should be discarded.

ADVERSE EFFECTS: Gastrointestinal discomfort, light sensitive rash, itching, diarrhea, fever, renal side effects.

DRUG INTERACTIONS: Oral contraceptive effectiveness is decreased, oral anticoagulants efficacy is increases : barbiturates, carbamezepine and phenytoin: decrease doxycycline effectiveness: antacids: impair its absorption.

DOSAGE: Oral adults: 100 mg every 12hours during first 24 hours, following by 100 mg once daily or twice daily in severe infections. Children above 8 years : 4-5 mg/kg body weight/day divided into two equal dose given every 12 hours the first day followed by half the dose as single daily dose. 200 mg iv in one or two infusions on first and 100-200 mg on subsequent days in adults.