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PRODUCT TYPE:- HYDRALAZINE / DIHYDRALAZINE
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It is a directly acting arteriolar vasodilator with little action on venous capacitance vessels; reduces total peripheral resitance and thus corrects a primary abnormally of hypertension. It causes greater reduction of diastolic than systolic BP, causes reflex tachycardia and therefore is often combined with beta blockers to null each others side effects.
INDICATIONS: Moderate to severe hypertension not controlled by the first line drugs. Hypertension with renal involvement.
DOSAGE: 25-50 mg once to thrice daily.
CONTRA-INDICATIONS: Pregnancy, elderly, Ischaemic heart disease, tachycardia, aortic or mitral stenosis, dissecting aortic aneurysm, idiopathic, constrictive pericarditis.
SPECIAL PRECAUTIONS: Liver impairment, severe renal failure, lactation, coronary or cerebrovascular diseases. Abrupt withdrawal.
SIDE-EFFECTS: Facial flushing, throbbing, headache, dizziness, palpitation, nasal stuffiness, paresthesias, tremors, muscle cramps, edema, lupus erythermatosus or rheumatoid arthritis like symptoms.
DRUG INTERACTIONS: Triccyclic antidepressants and monoamide oxidase inhibitors may increase the effects of hydralazine. Adrenaline enhances cardiac accelerating effect.