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It is a long acting second generation Calcium Channel Blocker. It acts by inhibiting the movement of Calcium through the slow channels of cardiac and vascular smooth muscles thus inducing peripheral vasodilation with consequent reduction in elevated Blood Pressure. Nitrendipine inhibits contractions of vascular smooth muscles induced by various stimuli, and does not alter conduction through sinus or arterioventricular node.
INDICATIONS: Mild to moderate hypertension hypertension.
DOSAGE: 5-20 mg once daily in morning. Max. 40 mg/day in 1-2 doses.
SIDE-EFFECTS: Headache, flushing, oedema, palpitations.
DRUG INTERACTIONS: Synergistic effect on angina with beta blockers. Reduced plasma levels of quinidine. Theophylline & phenytoin raise plasma levels. Cimetidine increases bio-availability & may potentiate hypotension.