Diamox
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It is a Carbonic Anhydrase inhibitor. Its effect is inhibition of HCO. Reabsorption which results in prompt mild alkaline diuresis. Other extra renal actions are lowering of intraocular tension due to decreased formation of aqueous humour (it is rich in HCO3). Raised level of carbon dioxide in brain & acidosis helps raising seizure threshould, sedation.
INDICATIONS: Epilepsy, adjunct in treatment of oedema due to CHF. Open angle, secondary & acute angle closure glaucoma.
DOSAGE: Epilespy: 8-30 mg/kg body not daily in divided doses.
Glaucoma: 250mg-1gm daily.
CONTRA-INDICATIONS: Liver disease (may precipitate hepatic coma). Pregnancy. Adrenal insufficiency. Sodium or potassium depletion. Renal hyper-chloraemic acidosis, prolong therapy in chronic non-congestive angle diabetes, potassium supplements may be required.
SIDE-EFFECTS: Acidosis, hypokalemia, drowsiness, paresthesias. Hypersensitivity reactions, fever, rashes.