Itropin
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It is naturally occurring organic amine. It is much less potent than Adr. On alpha & beta adrenergic receptors. It additionally acts on dopaminergic (D2) receptor in renal & mesenteric blood vessels, diates them. On heart, it has positive inotropic but little chronotropic effect. I.V.infusion raises cardiac output & systolic BP, little effect on diastolic BP.
INDICATIONS: Hemodynamic imbalances present in shock syndrome caused by hypovolaemia, myocardial infarctiontrauma, endotosins, septicaemia, open heart surgery, acute renal failure & chronic cardiac decompensation in congestive failure.
DOSAGE: Adult: 2-50 mcg/kg/min/ can be increased upto 100 mcg/kg/min by slow i.v. infusion.
Children: 2-20 mcg/kg/min/
CONTRAINDICATION: Pheochromocytoma, uncorrected tachycardia, ventricular fibrillation & hyperthyroidism.
SIDE-EFFECTS: Nausea, vomiting, ectopic beats, tachycardia, anginal pain, palpitation, hypotension, dyspnoea, headache and vasoconstriction.
DRUG INTERACTIONS: Anaesthetics may causes cardiac arrhyththmias, MAOIs increases the effect of dopamine.