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It Is A Cardiac Glycoside Which Increases Myocardial Contractility Be Direct Action (Positive Inotropic Effect). It Depresses A.V. Condition And Decreases Heart Rate. It Is Very Effective In Low Out Put Cardiac Failures. After Its Administration, Urinary Output Increases Due To Improvement In G.R.F. And Shift Of Extravascular Fluid (Oedema) To Vascular Compartment Due To Decreases In Venous Pressure.

Indications: Congestive Heart Faiure (Low Output, Atrial, Fibrillation, Arterial Flutter And Paroxysmal Supraventicular Tachycardia.

Contraindications: Hypokalaemia, Hypomagnesmia, Hypercalcemia, Ventricular Tachycardia, A.V. Block, W.P.W. Syndrome, Constrictive Pericarditis.

Safety Profile: Elderly, Thyrotoxicosis, Renal Or Hepatic Deseases, Acute Myocardial Infarction.

Adverse Effects: Nausea, Vomiting, Anorexia, Abdominal Cramps, Mental Confusion, Ventricular Premature Beats, Ventrucular Tachycarida And Fibrillation. Rarely Atrial Arrhythmias. In Case Of Cardiac Toxicity. Manifested As Tachyarrhythmias, Lignocaine (Xylocaine, Lidocaine) In The Dose 2-4 Mg/Kg Is Given As Bolus Intravenously Followed By 2-4 Mg Per Min. As Intravenous Infusion. Other Drugs Used Are Dilantin Sod., Propranolol And Antiglycoside Antibodies. Brady-Arrhythias Are Managed By Atorpine.

Drug Interactions: Quinidine, Verapamil, Captopril And Aminocardone Increase Plasma Concentration Of Digoxin. Hypokalemia Indduced By Diuretics And Hypercalcemia Precipitate Toxicity. Antacids And Sucrafate Decrease Its Absorption.

Dosage: Initially 0.25-1.5 Mg Daily. Maintenance Dose 0.25 To 0.5 Mg Daily. Children 10-20 Mcg / Kg Daily.