Lozol
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It is a vasodilator & diuretic related to thiazides. It reduces BP at doses which cause little or no diuresis. Electrolyte disturbances and K+ loss are minimal with antihypertensive doses. It reduces total peripheral resistance while cardiac output remains unchanged. Indapamide acts probably by interfering with ionic fluxes, including that of ca++ across vascular smooth muscle cells.
INDICATIONS: Hypertension.
DOSAGE: 2.5 mg daily.
CONTRA-INDICATIONS: Children, anuria, hepatic dysfunction.
SPECIAL PRECAUTIONS: Severe renal failure.
SIDE-EFFECTS: G.I. upset, fatigue, muscular cramps, debility, Hypokalaemia, hyper uricaemia. Reduction in glucose tolerance.
DRUG INTERACTIONS: Potentiates anti-hypertensive Probenecid competitively inhibits the tubular secretion, increases serum lithium levels.