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It is ethyl ester prodrug of a non-sulfhydryl angiotension converting enzyme (ACE) inhibitor. The effect of trandolapril in hypertion of appears to result primarily from the inhibition of circulating and tissue ACE activity thereby reduction angiotensin II formation, decreasing vasoconstriction, decreasing aldoserone secretion, and increasing plasma rennin. Decreased aldosterone secretion, leads to diuresis, natriuresis, and a small increase of serum potassium.
INDICATIONS: Hypertension.
DOSAGE: 2 to 4 mg once daily. Patients inadequately treated with once-daily dosing at 4 mg may be treated with twice-daily.
CONTRAINDICATIONS: Hypersensitive, patients with a history of angioedema.
SIDE-EFFECTS: Cough, dizziness, diarrhea, and hypotension, AV first degree block, bradycardia, edema, flushing, hypotension, palpitations drowsiness, insomnia, paresthesia, vertigo, rash, perphigus, abdominal distention, abdominal pain/cramps, constipation, dyspepsia, diahhhea, vomiting, pancreatitis.
SPECIAL PRACAUTIONS: Impaired renal function, hyperkalaemia and potassium-sparing diuretics, cough.