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It Is An Inhibitor Of Hmg-Coa Reductase, A Rate Limiting Enzyme In Cholesterol Synthesis. Inhibition Of Chollesterol Syntesis In The Liver Leads To Upregulation Of Ldl Recptors And An Increase In Catabolism Of Ldl Cholesterol. It Decreases Both Normal And Raised Ldl C, By Increased Catabolism And Decreased Production. It Also Decrease Apolipoprotein-B, Vldl, Plasma Triglycerides And Increase Hdl.

Indications: Hyperlipidemias – Primary Hypercholestrolemia (Heterozygous Familial And Non Familial), Mixed Dyslipidemia (Ii A And Ii B) In Patients Who Have Not Responded Adequately To Diet And Other Appropriate Measures. Prevention Of Coronary Events. Need For Revascularisation Proceduress And To Slow Progression Coronary Atherosclerosis In Patients With Coronary Heart Disease.

Contraindications: Active Liver Diseases Or Increased Serum Transaminase, Hypersensitivity To Any Component, Renal Impairment, Pregnancy, Lactation.

Adverse Effects: Pravastatin Is Generally Welltolerated, And Side Effects Are Rare. Minor Side Effects Includes Constipation, Diarrhoea, Fatigue, Gas, Heart Bum, And Headache. Major Side Effects Include Abdominal Pain Or Cramps, Blurred Vision, Dizziness Easy Brusing Or Bleeding, Itching, Muscle Pain Or Cramps, Rash, And Yellowing Of The Skin Or Eyes.

Dosage: Adult Dose
Initial: An Initial Dose Of 10 Mg. Once A Day Is Recommended In Patients With Significant Renal Function Impairment Or Hepatic Function Impairment And For The Elderly.
Maintenance: 10 To 40 Mg Once A Day At Bedtime. In The Elderly, Maintenance Doses Of 20 Mg, A Day Or Less Are Usually Effective.