Primacor
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It is a relatively selective inhibitor of peak III cyclic AMP phosphodiesterase isozyme in cardiac and vascular muscle. In patients with CHF it produces dose related and plasma drug concentration related increase in the maximum rate of left ventricular pressure. Milrinone has a direct inotropic and direct arterial vasodilator acitivity.
INDICATIONS: Adults: Administer by i.v. infusion over 10 mins., diluted before use. Initiate therapy with 0.50 mg/kg followed by intravenous infusion at a rate of 375-750 nanograms/kg/min., usually for upto 12 hours following surgery of 48-72 hours in CHF. Max. daily dose 1.13 mg/kg.
CONTRAINDICATIONS: Hypersensitivity to the drug.
SPECIAL PRECAUTIONS: Monitor fluid and electrolyte changes, blood pressure and heart rate. Do not use in patients with severe obstructive aortic or pulmonic valvular diseases.
SIDE-EFFECTS: Headache hypokalemia, tremors. Ventricular arrhythmias (including ventricular ectopic activity), hypotension nonsustained/sustained ventricular tachycardia, angina, ventricular fibrillation.