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INDICAITONS: All grades of hypertension, hypertension associated with diabetes mellitus, CHF

CONTRAINDICATIONS: Aortic stenosis, renal impairment and hypsensitivity.

SAFETY PROFILE: Monitor WBC counts when used with other leucopenic drugs. Correct sodium depletion before start of therapy, avoid concomitant use of k+ sparing diuretics.

ADVERSE EFFECTS: Drug cough, rashes, change in taste sensation, vertigo, faintness, anaemia, granulocytopenia proteninuria, hyperkalamia.

DURG INTERACTIONS: NSAIDs may reduce hypotensive action and may increase risk of renal toxicity, Raised levels of lithium.

DOSAGE: Start with 10 mg daily. Increase the dose gradually.Max. dose 80 mg, Maintenance dose 20-40 mg daily. Lower dose 2.5 mg daily in CHF.