Pronestyl
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It is an amide derivative of the local anaesthetic procaine which was found
to have antiarrhythmic activity but was not suitable clinically due to rapid
hydrolysis and marked C.N.S. effects. Procainamide is an alternative drug
to quinidine, having the same spectrum of efficacy. For I.V. use it is safer
than quinidine and has a more rapid action.
INDICATIONS: Premature ventricular contractions & tachycardia. Atrial fibrillation. Paroxysmal atrial tachycardia. Cardiac arrhythmias associated with anaestesia & surgery.
CONTRA INDICATIONS: Systemic lupus erythematosus (SLE), A.V. block.
SPECIAL PRACAUTIONS: Myasthenia gravis, donot interact with sulphonamides, renal & hepatic dysfunction, cardiac failure.
SIDE-EFFECTS: Nausea, vomiting, weakness, mental confusion, hallucinations, flusing, hypotension, angioedema, agranulocytosis.
DRUG-INTERACTIONS: Potentiates neuromuscular blocking agents. Impaired action of neostigmine and pyridostigmine. Neutropenia / Stevens-Johnson syndrome with captopril. Inhibits sulphonamides. Enhances effect of some beta-blocker. Effect enhanced by cimetidine, amiodarone, alcohol increases elimination.