Reopro
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INDICATIONS: Platelet aggregation inhibition as adjunct to percutaneous transluminal coronary angioplasty or atherectomy (PTCA).
DOSAGE: 0.25mg/kg administered 10-60 minutes before the start of PTCA, followed by a continuous i.v. injection of 10mcg/min for 12 hours.
SIDE-EFFECTS: Constipation, ileus, bleeding, thrombocytopenia, atrial fibrillation/flutter, complete AV block, palpitation, SVT, abnormal thinking, dizziness, human antichimeric antibody development.
SPECIAL PRECAUTIONS: Free plasma concentration of the drug decreases rapidly with an initial half life of < 10 min. and a second phase half life of 30 minutes, Platelet function recovers over the course of 48 hours.