Spironolactone
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It is a potassium retaining
(sparing) diuretic.
Indication: Hypertensin, oedema due to C.H.F. or cirrhosis or nephritic syndrome. Because of its antiandrogenic activity, it is also used in female hirsutism.
CONTRAINDICATIONS: Anuria, hyperkalemia, renal failure, Addison's disease.
SAFETY PROFILE: Pregnancy, drowsiness, ataxia, gynocomastia and G.I. upset.
ADVERSE EFFECTS : Headache, drowsiness, ataxia, gynocomastia and G.I. upset.
DRUG INTERACTIONS: Hyperkalemia with ACE inhibitors, Increased conc. Of digoxin and reduced efficacy of warfarin.