Ticlid
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It is a potent inhibitor of platelet aggregation induced by adenosine disphate and it also inhibits aggregation due to collagen, adrenaline, arachidonic acid, thrombin and platelet activating factor. When taken orally. Ticlopidine causes a time and dose dependent inhabitation of both platelet aggregation and release of platelet granule constituents, as well as prolongation of bleeding time.
INDICATIONS: Cerebrovasular disease such as transient ischaemic attacks (TIA), reversible is chaemic neurological deficit(RIND), stroke; coronary artery disease such as unstable angina, coronary artery by-pass grafts (CABG) secondary prevention of myocardial infarction; extracorporal shunts such as for haemodialysis and diabetic retnopathy.
DOSAGE: 250 mg twice a day with meals.
CONTRAINDICATIONS: Hypersensitivity, haemorrhagic diathesis, gastrointestinal ulcer, liver dysfunction, presence of haematopoietic disorders.
SIDE-EFFECTS: Diarrhea, nausea, vomiting, G.I. pain, skin rashes, vertigo, cholestatic jaundice.
DRUG INTERACTIONS: Risk of heamorrhage increased with aspirin and oral anticoagulants, increase in plasma level of ticlopidine with cimetidine, increase in theopylline half-life, decreases plasma digoxin levels.