Trental
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Trental SR (Pentoxifylline)
US Brand: Trental SR
Manufacturer: Other
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A homologue of theophylline and phosphodiesterase inhibitor; it has been shown to increase blood flow in ischaemic areas by reducing whole blood viscosity and improving flexibility of RBCs. The rheological (dealing with the property of flow) action, rather than vasodilatation is held responsible for improving passage of blood through microcirculation. Thus, there are no chances of ‘steal phenomenon’. Thus, there are no affect heart rate, peripheral resistance and BP.
INDICATIONS: Cerebrovascular insufficiency. Peripheral occulusive arterial disease & circulatory disorders of arterio sclerotic, diabetic, inflammatory or functional orgin. Trophic disorders. Lower leg ulcers & gangrene. Circulatory disorders in the eye.
DOSAGE: 400 mg, 2-3 times daily. Inj.15 ml by slow i.v. infusion in 250-300 ml normal saline over 3 hrs.
Repeat 2-3 times daily.
CONTRAINDICATIONS: Retinal haemorrhage, acute MI, severe haemorrhage, hypersensitivity.
SIDE-EFFECTS: Nausea, vomiting, dyspepsia, bloating, flushing, vertigo.
DRUG INTERACTION: Potentiate antihypertensives.