Xanthinol Nicotinate
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It enhances blood flow to the peripheral and cerebral tissues. Nutritive micro-circulation is enhanced by increasing by increasing the erythrocyte elasticity, improving the flow properties of the blood and reducing the peripheral resistance while simultaneously improving cardiac function. It improves cerebral metabolism and consequently cerebral function by increasing the glucose uptake across the blood-brain barrier and increase in glucose and oxygen utilization in the brain cells. It also depresses raised serum lipid and fibrinogen levels and inhibits platelet aggregation.
INDICATIONS: Peripheral vascular disease. Disordered cerebral function. Hyperlipidaemia.
DOSAGE: 300-600 mg 3 times daily with meals.
Retard: 0.5g-1 g. 2 times daily with meals
Hyperlipidaaemia: 1 gm 3 times daily.
CONTRA INDICATIONS: Recent myocardial infarction, recent cerebro-vascular accident, acute faemorrhage, decompensated cardiac insufficiency.
SIDE-EFFECTS: Flushing (reddening of skin & sensation of heat).
DRUG INTERACTIONS: Concomitant use of ganglion blockers and sympatholytic agents should be avoided.