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DEXAMETHASONE: Very potent and highly selective glucocorticoid. Long acting. Causes marked. pituitary-adrenal suppression, but retention and hypertension are not a problem. It meets any emergency with intensified protency and. strikingly rapid corticosteroid action, thus ensuring speedy reversal of the situation in the patients favor.

Indication: Allergic reaction pre & post-operatively. Acute stage of infections. poisoning, adernocortical insufficiency. Shock, acute dermatological disorders, rheumatic disorders, ophthalmologic disorders.

Dosage: 4-20 mg/day i.v. infusion or i.m. 0.55 mg/day orally.

Contra-indication: Renal failure, diabetes mellitus, psychosis, osteoporosis. Pregnancy CHF, tuberculosis & other systemic infections

Special Precautions: May reduce the response of the pituitary-adrenal axis to stress. Glaucma, epilepsy, hypertension. Liver dysfunction. Elderly.

Side-effects: Cushing’s habitus (rounded face, narrow mout). Fragile skin, bruising, telengiectasis, hirsutism. Cutaneous atrophy occurs with topical use. Hyperglycaemia, glycosuria, muscular weakness. Delayed heating of wounds & surgical incisions.

Drug Interaction: Phenytoin, phenobarb, ephedrine and rifampicin reduce efficacy G.I. absorption reduced by megnesium trisilicate. Salicylates efficacy reduced.

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