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PROGESTOGEN-ESTROGEN COMBINATION : It is indication for the treatment of gynaecological disorders in which temporary supression of ovarlan function is desirable. It is taken regularly, there will be maturation of the follicles and no ovulation during the treated cycles. Its influence on the endometrium can also be put to therapeuctic use and the lengh of the cycle is normalised.

Indications: ORAL CONTRACEPTICES Dysmenorrheal, endometriosis, irregularities of the cycle without organic cause (hypermenorrhoea, polymenorrhoea, intermentrual bleeding), intermenstrual pain (Mittleschmerz).

Dosage: 1 Tablet daily from 5th to the 25th day of the cycle after meals. First day of bleeding is counted always as day 1 of the cycle.

Contra Indication : Pregnancy, severe disturbances of liver function, jaundice or presistent itching during a pervious, Dubin-Johnson syndrome, Rotor syndrome, liver tumours, thromboembolic processes, sickle-cell anaemea, cancer of breasr or endometrium, diabetes, herpes of pregnancy, oteosclerosis,

Special Precautions: Before starting, medical & gynecological examination (including the breasts should be carried out pregnancy must be exclude.

Cigarette smoking. Thromoembolic disorders. Preexisting uterine liiomyomata may increase in size. Mental depression, fluid retention, chlistact jaundice. Disturbed tryptophan metablism. Lactation.

Side-effects: Nausea, vomiting. G.I. upset. Change in menstrual flow. Dysmenorrheal. Chlosma or melasma. Breast changes, weight gain. Cervical erosion or cercical secretion. Rash. Vaginal candidasis.

Drug Interaction: Decrease effect of tricyclice antidepressants, hypoglycaemic agents, anticoagulants. Rifamipicin, barbiturates and phenytoin interfere with effects.