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BETAMETHASONE : It is a glucocoricosteroid which is about eight ot ten times as active as prednisolone on a weight for weight basis. It is similar to dexamethasone, probably a little a more potent & has a potent & has a ptential to cause dramatic improvement in many sever diseases as well as produce quality dra,atoc advers effect if not properly used. The use in non endocrine diseases is empirical and palliative, but may be life saving.

Dosage: 4-20 mg i.v. infusion or i.m. 3-4 times a day.

Children: Infants up to 1 yr. 1mg i.v.; 1-5yrs 2mg 6-12 yrs. 4mg i.v. or i.m.. 0.5-5 mg/day orally.

Contra-indication: Systemic infections, unless specific ant-infective therapy is employed. Live virus immunization.

Special Precautions: May impair the ability t resist and counteract infection. Due to fluid retention care in congestive heart failure. Diabetes mellitus, osteoporosis, hypertension, galucoma & glaucoma & epilepsy, previous steroid mypathy or peptic ulceration. Growth retardation in infancy, chilhood & adolescence. Elderly. Pregnancy.

Side-effects: Sub capsular cataract, skin thinning. Osteoporosis and glaucoma. Osteonecrosis particularly of femoral head. Peptic ulceration, altered fluid & electrolyet balance, intacranial hypertension & psychic instability.

Drug interaction: Reduced efficacy with concurrent use of carbamazepine, phenytoin, primidonea and barbiturates. Rifampicin reduces corticosteroid activity. Peptic ulcer with concurrent NDSAI’S administratin. Dose of antidiabetics and antihyper tensives needs to be incerases serum concentration of salicylates and antimuscarinic agents.