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GLIBENCLAMIDE: Single dose provoke a brisk release of insulin form pancreas. It acts on Beta cell membrane leading to enhanced calcium flux across in hence dgranulation. After chronic admin, the insulinemic action of Glibenclamide declines, but improvement in glucose tolernce is maintained. Thus an oral anti-diabetic preparation with an effcient hypoglycaemic action.

Indications: Non-insulin dependent Diabetes Mellitus. Patients who have failed to repond to other oral antidiabetic drugs.

Dosage: Intially 2.5mg daily as a single dose at breakfast increasing gradually by another 2-5mg (only after repeating laboratory examinations.) Max 15mg daily.

Contra-indications: Insulin-dependent Diabetes Meellitus. Diabetic coma, severe metabolic decompensation (Keto acidosis) severe renal impairment, hypersensitivity, pregnancy.

Special Precautions: In undrweight, unsual physical exercise or irregular meals maeais hypoglycaemai may occur. Symptoms of hypoglcaemia are headache, irritability. emotional dejection, restlessness, insomnia, termor, profuse weating, impairment of performance & alertness. Glibeclamide should always be taken immediately before or along with substantial meals.

Pediatric: Not recommended.
Pregnancy & Lactation: should not be used
Elderly: Reduced dose may be necessary.

Side-effects: Naisea, vomiting, anorexia or a feeling pressure or fullness. Pruritus, urticaria, leuco-[emoa, thrombocytopenia.

Drug Interaction : Warfarin, salicylates, sulphonamides and alconol potentiate hypoglycaemic effect. Glucocorticoids, diuretics and estrogen reduce hypoglycaemic effect. Synergistic hypglycaemic action with metformin.