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DESMOPRESSIN : It Is a analogue of vasopressin (ant diuretic hormone, ADH)
Indication : Diabetes insipid us. Primary nocturnal enuresis. Nocturia associated with multiple sclerosis. Renal function testing.
Dosage: Intranasal : Diabetes insipid us diagnosis: Adult and child 20 mcg. Diabetes insipid us treatment-Adult 10-40mcg daily (in 1 or 2 divided doses) child 5-20 mcg. Infants may require lower doses.
Contra-indication: Cardiac insufficiency, other conditions treated with diuretics.
Special Precautions: Renal impairment, cardio-vascular disease and hypertension (not indicated for nocturnal enuresis and nocturia in those over 65 years),cystic fibrosis.
Side-effects: Fluid retention, hyponatraemia on administration without restricting fluid intake, stomach ache, headache, nausea, vomiting, epistaxis. Alergic reations ranging from urticaria to anaphylaxis may occur.