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GLIPIZIDE: It is one of the second generation sulfonyl rears, having a similar pharmacological protile, as that of Glibenclamide or glictazide.
Indications: Non- insulin dependent diabetes meellitus.
Dosage: 2.5-5 mg daily v2hr before meals. Gradually increase by 2.5-5 mg at weekly intervals to m,ax 20mg daily.
Contra indications: Juvenile Diabetes mellitus. Pregnancy, stress. Renal or hepatic dysfuctions impaired adrenocortical function ketoacidosis. Diabetic pre-coma & coma.
Special precautions: Hypoglycemia. It should be taken before or along with meals. Underweight severe hepatic or renal disease.
Paediarics : Saffety and efficacy not established.
Pregnancy : Should not be used
Lactatio : Use with caution
Elderly Reduced dose may be necessary
Side effects: Nausea, urticaria, thrombocytopenia, vomiting, diarhoea, drowsiness, headache, pruritus.
Drug Interaction: Hypoglcaeia enhanced by alcohol, sulphonamides, tir-methroprim,e\salicylate, & b blockers antagonise hypoglycemic action. Food delays absorptiion