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ALLYLOESTRENOL
Allyloestrenol is a synthetic progesterone derivative. This drug is used in threatened pregnancies to stop premature birth of a child. It stops labor from occurring before the proper time. Thus, it can help women to give birth to a healthy baby.
As the drug is used in pregnant women, one should be extra cautious while using Allyloestrenol. It should not be used without supervision by a doctor. Its effect on the patient should be carefully monitored. It is also essential to use the right amount of the drug. Then only the desired positive effects can be got.
Precaution should be taken by diabetic pregnant women and the women who have heart or kidney related problems..
Technical detail
It has pronounced pregnancy-maintaining action in castrated animals without producing, hormonal side-effects. In the human premature termination of pregnancy often follows a fall in the level of placental hormones. Allylestrenol has been shown to stimulate the placental progestrone production & promote the secretion of placental hormones (H.C.G., human placental lactogen, oestrogens and progesterone) and oxytocinase in patients with pregnancy at risk.
Indications: Threatened abortion. Habitual abortion. Threatened premature labour metrorrhagia & premenstrual tension.
Dosage: Threatened abortion: 5 mg 3 times daily for 5-7 days then reduce gradually till symptoms disappear. Habitual abortion : 5-10 mg daily as soon as pregnancy has been diagnosed, till critical period is over. Threatened premature labour - Individually (upto 40 mg daily).
Contra-indications: Undiagnosed abnormal vagina bleeding. Mammary or genital carcinoma. Hepatic impairment. History of thromboembolic disorders.
Special Precautions: Migraine, epilepsy, diabetes.
Side-effects: G.I complaints like nausea, vomiting.
Drug Interaction: Decreases effect of tricyclic antidepressants, hypoglycaemic agents anticoagulants. Rifampicin, barbiturates and phenytoin may interfere with effects.