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PRODUCT TYPE:- PIOGLITAZONE WITH METFORMIN
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PIOGLITAZONE: It is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. It decreses insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output.
Indication: It is an adjunct to diet and exercise combination with a sulfonylurea, metformin, or dose insulin when diet and exercise plus the single agent dose not result in adequate glycemic control.
Contra-indications: Hypersensitivity.
Special Precautions: In patients with type 1 diabetes or for the treatment of diabetic ketocidosis. oral hypoglycemic agents may be at risk for hypoglcemia, therapy may result in ovulation in some premenopausal anovulatory women. In patient with edema.
Dosage: In patient not adequately controlled with diet and exercise may be intiated at 15mg or 30mg once daily. For patients who respond inadequately to the intial dose of it, the dose can be increased in increments upto 45mg once daily. In combination with a sulfonylurea may be initiated at 15mg or 30mg once daily. In combination with insulin may be intiated at 15mg or 30mg once daily.
Side-effects: Headache, upper respiratory tract infection, myalgia, sinusitis and oharyngitis.
Drug Interactions: Oral Contraceptives.