Gonotrop f
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MENOTROPHIN (oradotrophins) : The anterior pituitary secretes two gonadotrophins FSH & LH Both act in concert to promote gametogenesis and secretion of gonadal hormones.
FHS in the females induces follicular growth,development of ovum & secretion of estrogens. In the male it supports spermatogenesis and has a trophic influence on seminiferous tubules. Ovarian and testicular atrophy occurs in the absence of FSH. LH induces preovulatory swelling of the ripe graffian follicle and ovulation in female. It then bring about lutenization of the ruptured follicle and maintains corpous luteum till the mestrual cycle. Progesterone secretion occurs only under the influence of LH. In mle LH stimulates testosterone secretion. Inadequate gonadotrphin scretion results in amenorrhea & sterility in women; oligozoospermia, impotence and infertility in men.Menotrophin is a preparation obtained from urine of menopausal women.
Indications: Amenorrhea and infertility. Hypogonadotrophic hypogoadism in males & females. Follicle stimulation in I.V.H Cryptorchism.
Dosage: It varies from patient to patient & in the same patient at different times. This can be ducted by carrying our hormonal assays. Schedulae I :- 3 equal doses given on alternate days. Schedule II :- Give daily till response is achieved.
Contra-Indications : Pregnancy.
Special Precautions : Skin tests advised to avoid allergic reactions. Hormone dependent mailgnancies (prostate, breats) must be excluded. Precocious puberty is risk in children.
Side-effects: Multiple pregnancy, sensitivity reaction, polycystic ovary, pain in lower abdomen, ovarian, polycystic ovary, pain in lower abdomen, Varian bleeding.