Luteum Depot
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HYDROXYPROGESTERONE:
Its main function, like other Progesterone derivatives is preparation of
uterus for nidation and maintenance of pregnancy. The latter is probably due to decreased uterine motility and inhibition of immunological rejection of
the foetus: progesterone decreases T-cell function find cell mediated immunity.
Indications: Habitual & threatened abortion, infertility due to corpus luteum insufficiency, primary & secondary amenorrhoea, uterine hypoplasia.
Dosage: Habitual abortion: 250-500mg i.m: weekly.
Threatened abortion: 500 mg i.m. 2-3 times weekly. Infertility: 250 mg i.m.3 days after rise in basal body temp.
Contra-indications: History of herpes of pregnancy, previous or existing liver tumours. Special Precautions: Diabetes. Exclude pregnancy in indications other than threatened or habitual abortion. Intra abdominal haemorrhage due to malignant liver tumours.
Side-effects: G.I. disturbances, weight gain oedema, acne, increased appetite, urticaria, allergic skin rashes, mental depression. Drug Interaction : Potentiates CNS depression by alcohol, barbiturates, hypnotics, opioid analgesics, sedatives and neuroleptics, MAOIs, atropine, and tricyclic antidepressants potentiate antimuscarinic effects. Incompatibility with aminophylline, ben-zylpenicillin, chloramphenicol, sodium-succinale.