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Drugs recommanded are:

• Provera

Natural Micronised Progesterone : A micronised porgesterone, identical to that secreted by the human ovary, with improved bioavailability.

Indications : Sterility due to luteal deficiency; treatment of puerperal depression; maintenance of pregnancy in cases of threatened or habitual abortion; premenstrual syndrome; benign mastopathies; DUB; in menopause to reduce the risk of endometrial hyperplasia and carcinoma in post-menopausal women receiving conjugated oestrogens.

Dose: Maintenance of pregnancy- in cases of habitual or threatened abortion: 200 to 400 mg per day in divided doses.

For premenstrual syndrome: 200-400mg 1-2 times daily from the 12th to 14th day of the cycle until onset of menstruation.

For puerperal depression: 400 mg twice daily in divided closes.

Supplementation of the luteal phase in case of sterility due to luteal deficiency: 400 to 600mg per day up to the 12th week of pregnancy.

Contraindications: Hypersensitivity, undiagnosed vaginal bleeding, abnormal liver function, hormone dependent carcinoma, thrombophlebitis, thromboembolic disorder, cerebral.

Special Precaution: Epilepsy, migraine, asthma, cardiac or renal dysfunction. Avoid driving or operating hazardous machinary. Monitor diabetic patients receiving oestrogen-progesterone combination therapy. Pregnancy: If given in the second and third trimester of pregnancy it can lead to a severe cholestatis or hepatitis.

Side effects: Drowsiness, giddiness, weight gain or loss and skin reactions such as acne. Soreness, diarrhoea and flatulence may occur after rectal administration, menstrual irregularities or intermenstrual bleeding.