Abrocef
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CEFUROXIME:It is resistant to most betalactamases and is active against a wide range of Gram-positive and Gram-negative organisms. The most important use of cefuroxime is meningitis caused by H. influenza, meningococcal and peneumococi, because it attains high concentrations in C.S.F.
Indications: Respiratory tract, Bonito-urinary tract skin and soft tissue infections. Gonorrhea, acute gonococci arthritis and servilities Meningitis, Prophylaxis against infections in surgical procedures.
Dosage: Adults: 750 mg thrice daily I’m. Or ivy. Severe infections: 1.5 gm thrice daily ivy. Total dose 3-6 gm daily.
Infants and children: 30-100 mg/kg body us daily in 3-4 divided doses.
Neonates: 30-100mg/kg body we in 2-3 divided dose
Meningitis: 200-240 mg/kg body wt ivy. daily in 3-4 divided dose.
Neonates: 100 mg/kg body wt ivy. daily
Contra-indications: Patients with know hypersensitivity to cephalosporin antibiotics
Special Precautions: Anaphylactic reaction to penicillin’s. Pseudo membranouscolitis.
Overgrowth of non-susceptible organisms.
Pediatrics: Not safe in children below 3 months.
Pregnancy: Use with caution.
Lactation: Use with caution
Side-effects: Skin rashes. Eosinophilia and transient increase of hepatic enzymes.
Drug Interactions: Synergy with aminohlycosides.