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Cefpodoxime proxetil
Cefpodoxime proxetil is a 3rd generation semi-synthetic cephalosporin and a beta-lactam antibiotic. It is used in the treatment of different types of bacterial infections. Cefpodoxime proxetil is active against most Gram positive and Gram negative bacteria.
It has been found in the Clinical studies that they have efficacy of cefpodoxime in sinusitis, acute otitis media and tosillopharyngitis. Cefpodoxime can be used as a therapy in respiratory in the areas where common respiratory pathogens show alower level of sensitivity to macrolides, and penicillins. Cefpodoxime is used in the treatment of infections of respiratory tract. This drug has good efficiency against common pathogens causing respiratory tract infections.
Technical detail:
CEFPODOXIME PROXETIL: It is a bactericidal and kills bacteria by interfering with the synthesis of the bacterial cell wall. It is stable in the presence of beta lantanas enzyme. A number if beta lantanas producing organisms resistant to penicillin/other cephalosporin are likely to be susceptible to cerpodoxime.
Indication and dosage: URTI including pharyngitis and tonicities: 100mg bid for 5-10 days. Acute exacerbation of chronic bronchitis 200 mg bid for 10 days. Acute community acquired pneumonia: 200 mg bid for 14 days. Acute uncomplicated gonorrhea: 200mg single dose. Uncomplicated urinary tract infection: 100 g bid for 7 days skin and skin structure infections: 400mg bid 7 to 14 days.
Contra indications: Hypersensitivity
Special precautions: Penicillin sensitive patients for patients with severe renal impairment the dosing interval is to be prolonged to 24 h. Inpatiens maintained on heamodialysis. Dose frequency to be adjusted to 3 times a week after hem dialysis.
Pediatrics: Safety and efficacy in infants less than 5 months of age have not been established.
Pregnancy: Avoid during pregnancy unless there are compelling clinical indications.
Side effects: Diarrhea, nausea, vomiting abdominal pain colitis and headache.
Drug Interactions: Antacids decrease the peak plasma levels; oral anticholinergics delay the attainment of peak plasma level. Probenecid inhibits renal excretion.