Benzyl pen
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PENICILLIN-G (BENZYL PENICILLIN):It is narrow spectrum with limited activity against arm positive bacteria. May bacteria are inherently insensitive to Pang because in them the target enzymes and penicillin binding protein are located deeper under lipoprotein barrier where Pang is unable to penetrate.
Indications: Streptococcal infections like Pharyngitis, obits media, scarlet fever, rheumatic fever, Pneumococcal like obits media, meningitis, and osteomyelitis. Gonorrhea. Syphilis, Diphtheria. Tetanus, gas gangrene. Trench mouth, Rat bites fever.
Dosage: Sod, Penicillin G. infection: 0.5-5 MU i.m. /i.v. 6-12 holy. Pot Penicillin-G oral use: 2-8 lace U Q.I.D. 1hrs after food.
Contra- indications: Hypersensitivity, Allergic
Diathesis, rash, tiching, urticaria, fever, wheezing angioneurotic edema.
Special Precaution: A scratch test or intradermal test may be performed first.
Side-effects: Paint at I’m. Injection site, nausea on oral ingestion, mental confusion, muscular, twitching, convulsions, coma, CNS stimulation, hallucinations, convulsions
Drug Interaction: Probenecid Increases and prolongs blood levels. Effects reduce by bacteriostatic agents like chloramphenicol and tetracycline.