POLYMYXIN B AND LOLISTIN: They are active against most gram negative bacteria, notably. Pseudomonas, exceptions are protease, Serration and Noisier. Both have very similar range of activity, but colitis is more potent on pseudomonas, Salmonella and shield. Little or no absorption occurs form oral route or even form denuded skin (burn, ulcers).

Indications: Systemic urinary tract. Ménage local and enteric infections caused by gram negative organisms.

Dosage: Polymeric B, 15,000-25,000 u/kg body wt daily for 7-10 days. Max 2,000,000 i.e. per day colitis sup hate: 25-100 mg 3 times orally daily children and infants. 5-15 mg/kg body wt in 3 divided doses.

Contraindication: Hypersensitivity.

Special Precaution: Perforated tympanic membrane, monitor renal functions.

Pediatric: Use with caution
Pregnancy: Contraindicated.
Lactation: Contraindicated.
Elderly: Use with caution.

Side-effects: Intra muscular injection causes pain flushing and prosthesis after injection. Nephrotoxicity, neurological disturbances, ototoxicity.

Drug Interaction: Potentates nephrotoxicity produced by cephalothin and amino glycosides. Neuromuscular blockade potentaiated by ether anesthesia, sedatives, muscle. Synergy with trimethroprim and useful combination with fifampicin

COLISTIN-
Drug Interactions: Potentates action of carafe form muscle relaxants. Nephrotoxicity of amino glycosides. Potentials chloramphenicaol erythromycin and trimethoprim