Generic Diflucan
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It is a fluorinated bistriazole and almost completely absorbed fro GIT. Plasma concentrations remain the same whether it is given orally or intravenously and bioavailability is not altered by food or gastric acidity.
INDICATIONS: Oropharyngal candidiasis, oesophageal candidiasis, vaginal candidiasis, vaginal candidiasis, deep candidiasis in allogenic bone marrow transplant recipients and candidemia of nonimmuno-suppressed patients. Cryptococcal meningitis of AIDS and coccidioidal meningitis respond well to fluconazole treatment. It is also active against histoplasmosis, blastomycosis, sporotrichosis and ringworm.
CONTRAINDICATIONS: Not any special.
SAFETY PROFILE : Patients should be warmed with the side effects of specially nausea and toxic oral azole drugs. The antifungal agents presently available fall in to several categories: systemic drugs for systemic infections and topical drugs fro mucocutaneous infections.
Vomiting of the drug. So antiemetic should be preadministered as precautionary measure for better compliance.
ADVERSE EFFECTS: Nausea, vomiting, headache, abdominal pain, diarrhea, skin rash, alopecia, hepatic failure leading death, stevens- Johnson syndrome, teratogenic in animals.
DRUG INTERACTIONS: Fluconazole significantly increases plasma concentrations of astemizole, cisapride, cyclosporine, rifampicin, rifabutin, sulfonylureas, theophylline, tacrolimus and warfarin. Rifampicin decreases concentration of fluconazole.
DOSAGE: For candidiasis 200 mg on first day and 100 mg daily orally thereafter for 2 weeks and for cryptococcosis 400 mg daily orally for 8 weeks. In general the dosage of fluconazole is 50-400 mg once daily orally or intravenously. Children are treated with 3 to 6 mg / kg once daily.