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It Is A Synthetic Imidazole Compound Administered Orally. It Was The First Oral Azole Introduced Into
Clinical Use.

INDICATIONS: Blastomycosis, Coccidioidomycosis, Pseudallescheriasis, Para-Coccidiodomycosis, Ringworm, Tinea Versicolor, Chronic Mucocutaneous Candidiasis, Candida Vulvovaginits And Oral And Esophageal Candidiasis, Nonmeningeal, Localized His Toplasmosis.

CONTRAINDICATIONS: Adrenal And Gonadal Dysfunctions, Hepatic Dysfunction, Hypertension.

SAFETY PROFILE: It Seems Prudent To Discontinue The Drug Before Major Surgical Procedures And To Avoid Using High Doses In Patients With Trauma, Severe Burns Or Other Stressful Conditions As It May Precipitate Addison’s Disease Type Symptoms. In Pregnancy Use Is Not Recommended Due To Teratogenic Effect In Animals.

ADVERSE EFFECTS: Nausea, Anorexia And Vomiting, Skin Rashes And Occasional Elevations In Aminotransferase Levels Leading To Total Hepatitis. It Blocks The Synthesis Of Adrenal Steroids And Testosterone And Can Cause Gynaecomastia And Impotence In Male. Infertility And Menstrual Irregularities Can Occour Due To Interference Of Biosynthesis Of Gonadal Steroid Hormones. Hypertension And Fluid Retention May Occur.

DRUG INTERACTIONS: It Inhibits Mammalian Cytochrome P 450 Enzymes And Can Cause Altered Metabolism Leading To Enhanced Toxicity. Other Drugs Like Cyclosporine, Midazolam, Warfarin, Triazolam, Indianvir, Phentoin And Cisapride. Other Drugs Accelerate Metabolism Of Ketoconazole Which Include Cimetidine, Rifampicin, Isoniazid And Rifabutin.

DOSAGE: Usual Adult Dose Is 400 Mg Taken Once Daily And Children Are Givem 3.3 To 6.6 Mg/Kg Daily. Duration Of Therapu Is 5 Days For Candida Vulvovaginitis, 2 Weeks For Candid Oesophagitis And 6 To 12 Months For Deep Mycosis.