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Valacyclovir is the hydrochloride salt of L-Valye ester of acyclovir. It converted to acyclovir which has demonstrated antiviral activity against herps simplex virus type 1(HSV-1), HSV-2 and varicellazoster virus (vzv) both in vitra and vivo. After oral administration valacyclovir is rapidly absorbed from the GI tract. It converted to and L-valine by first pass intestinal and/or hepatic metabolism. Acyclovir is converted to a small extent to inactive metabolites by converted to a small extent to inactive metabolities by aldehyde oxidase and by alcohol aldehyde dehydrogenase.

INDICATIONS: Herps zoster, genital herps, herpes labialis (cold sores).

CONTRAINDICATIONS: Hypersensitivity to valacyclovir or any components.

SAFETY PROFILE: Dosage should be reduced to patient of renal impairment, acute renal failure, elderly patients and patients receiving nephrotoxic agents.

ADVERSE EFFECTS: Nausea, diarrhea, vomiting, headache, anorexia, abdominal pain, dyspepsia.

WARNINGS: Thrombotic thrombocytopenic purpura / hepolytic uremic syndrome, in some cases resulting in death, has occurred in patients with advanced HIV disease and also in allogenic bone marrow transplant and renal transplant recipients participating in clinical trials at doses of 8 grams per day.

DRUG INTERACTIONS: Not reported.

DOSAGE: Herpes zoster: 1 gm 2 times daily for 7 days.

GENITAL HERPES
INITIAL EPISODES – 1 gm b.i.d. for 10 days.