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Ceftriaxone & vancomycin

Ceftriaxone/vancomycin combination is an antibiotic used to treat pneumococcal meningitis. Pneumococcal meningitis is an infection of inner lining of brain & spinal cord. I t is also used to treat infections of upper respiratory tract such as pneumonia. Pneumonia is a severe infection of lungs. This antibiotic is also used to treat infections of ears, bones & joints.

CEFTRIAXONE WITH VANCOMYCIN:It is indicated in the following infections due to susceptible organisms.

Pneumonia (Ventilated Associated Pneumonia, Hospital acquired Pneumonia, Bacterial Meningitis, Bacterial Endocarditic, Septicemia, infections in immunocompromised patients.

Dosage:Adjustment in Renal Impairment: Ceftiraxone is excreted via both military and renal excretion. Therefore, patients with renal failure normally require no adjustment in dosage when usual dose of ceftriaxone are administered. Dosage adjustment with vancomycin must be made in patients with impaired function. There are dosage reduction studies for the combination in renal impairment.