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Methocarbamol
It is used in skeletal muscle relaxation. It block spinal polysynaptic reflexes. It produce sedation also.
INDICATIONS: Skeletal muscle spasm. Neurological disease. In orthopaedic & surgical procedures.
CONTRAINDICATIONS : Hypersensitivity, coma, epilepsy, myasthenia gravis and known brain damage.
SAFETY PROFILE: Hepatic or renal disorders
ADVERSE EFFECTS: Headache, anorexia, nausea, vertigo, fever, drowsiness, skin eruption.
DRUG INTERACTIONS: CMS depressants
DOSAGE: Orally 500-1500mg 4-6 hourly, IV/IM-100-200MG 6 hrly.
Tetanus: 100-300mg. IV over 10-15 minutes. Then 200mg. every 6 hrs. until oral therapy can be started by dose of 18-40 tab (500mg.) daily in divided doses.