Doverin
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Drotaverine
It is a derivative of isoquinoline. It is used as spasmolytic drug. It exerts its action by inhibiting phosphodiesterase enzyme. It act on spasmodic site correcting cyclic AMP & Calcium imbalance thereby relieves the smooth muscle spasm.
INDICATIONS : Cholelithiasis, cholecystitis, nephrolithiasis, peptic ulcer, spastic constipation, smooth muscle spasm, control & prevention of pain & dysfunction due to smooth muscle spasms.
SAFETY PROFILE :
ADVERSE EFFECTS: It is free from CMS side effects addiction, dryness of mouth & blurring of vision, & blood dyscrasia.
DRUG INTERACTIONS: Effects of levodopa may be used if given concurrently.
DOSAGE: Adult : 40-80mg, thrice daily.
Children : 1-5 yrs. 20mg. 3-4 times daily.
6-12 yrs : 40mg thrice daily.