Nabuflam
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Nabumetone
It is a weak cox inhibitor and is converted by the liver to naphthylactic acid a potent inhibitor of prostaglandin synthesis, after oral administration 75-80 dose in excreted in the urine. Peak plasma concentration is reached after 2.5-4 hours.
INDICATIONS : Acute and chronic osteo-arthritis, soft tissue injuries.
CONTRAINDICATIONS : Hypersensitivity to the drug, history of NSAIDs or aspirin induced asthma peptic ulceration, allergic reactions.
SAFETY PROFILE : Impaired renal function. Liver dysfunction, patient look for sign and symptoms of bleeding and ulceration.
ADVERSE EFFECTS : Gastrointestinal ulceration and bleeding, dyspepsia, constipation, dizziness.
DRUG INTERACTIONS : Protein bound drugs (e.g. anti coagulants) are displaced from their binding sites. DOSAGE : Single dose of 1-2g OD at bed time, additional 500mg-1g may be administered the morn¬ing in case of severe or persistent symptoms or during acute exacerbation. Elderly 500mg daily, max daily dose should not exceed 1g.