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Tizanidine
It is centrally acting drug (muscle relaxant). It is D2 agonist structurally similar to clonidine.
INDICATIONS : Painful muscle spasm, spastic-ity due to neurological disorder.
CONTRAINDICATIONS : Hypersensitivity.
SAFETY PROFILE : Renal insufficiency, impaired renal function, driving vehicle or operating machinery.
ADVERSE EFFECTS : Drowsiness, fatigue, dizzi¬ness, dry mouth, nausea, GI disturbance.
DRUG INTERACTIONS: Antihypertensive, including diuretics may cause hypotension and bradycardia.
DOSAGE : Painful muscle spasm - 2mg. thrice a day. Spasticity- Daily dose should not exceed 6mg.