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Orphenadrine

It act centrally. It has analgesic property too.

INDICATIONS : Musculo skeletal disorders

CONTRAINDICATIONS: Narrow angle glaucoma, myasthenia gravis. Tardive dyskinesia. Prostatic hypertrophy.

SAFETY PROFILE : Renal or hepatic dysfunction, GI obstruction, Tachcardia urinary retention.

ADVERSE EFFECTS : Dizziness, restlessness, dry mouth, nausea, blurred vision.

DRUG INTERACTIONS: Anticholinergics, alcohol and other CNS depressants, Antagonises steroids, barbiturates and phenylbutazone, chlorpromazine, level. Hampers absorption of other drugs. Synergistic effect of levodopa.

DOSAGE : 50mg. three times daily. Max400mg daily increased gradually.

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