Fluoxetine HCL

Its antidepressant action seems to be due to it’s capability to inhibit CNS neuronal uptake of serotonin.

It is a potent anti depressant, not sedative.

Indications: it is used for the treatment of mild to moderate endogenous depression. It may be of use in treatment of obsessive-compulsive disorder, obesity and alcoholism.

Contradictions: Severe renal failure, hypersensitivity, nursing mothers.

Safety Profile: In pregnancy and lactation, Patients with epilepsy and mania, patients with hepatic, cardiac and renal diseases, operating machinery, driving.

Adverse Effects: Anorexia, diarrhea, nervousness, headache and insomnia quite common. May precipitate mania and hypomania. Urticaria and skin rashes, fatigue, tremors and sweating.

Drug Interactions: Tricyclic anti depressants; Reduces the breakdown of tricyclic anti depressants. Change in the lithium levels.

Dosage: Adults: Initially 20mg a day. Increase at 20mg/day upto maximum 80mg/ day in 2 divided doses.