Fluvator
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FLUVOXAMINE MALEATE
It is a selective serotonin (5-HT) receptor inhibitor (SSRI) It is chemically unrelated to other SSRI's and clomipramine. The mechanism of fluvoxamine is inhibition of neuronal (brain neurons) uptake of serotonin.
INDICATIONS: Treatment of obsessions and compulsions in patients with obsessive and compulsive disorders.
CONTRAINDICATIONS: Co administration of Terfenadine, astemizole or cisapride with fluvoxamine is contra indicated. Patient with history of hypersensitivity to fluvoxamine maleate.
SAFETY PROFILE: Activation of mania/hypomania, seizures, suicidal tendency, dysfunction, in presence of depressive symptoms, smokers, operating hazardous machinery, pregnancy: - use only if potential benefit justify potential risk.
ADVERSE EFFECTS: Asthenia, nausea, diarrhoea, dyspepsia, anorexia, dysphagia, insomnia, hypertonia, dyspnoea, headache, flu like syndrome and chills, constipation, vomiting, flatulency, tooth disorder, somnolence, dizziness, dry mouth, nervousness, tremor, anxiety, vasodilatation, agitation, decreased libido, depression, CNS stimulation, upper respiratory infection, yawn, sweating, taste perversion, abnormal ejaculation, urinary frequency, impotence, urinary retention.
DRUG INTERACTIONS: Fluvoxamine should not be used in combination with MAOI's or within 14 day's of discontinuing treatment with Mono-Amine-Oxidase Inhibitors (MAOI's). Drugs that are metabolized by and/or inhibits cytochrome P 450 isoenzymes: Clini¬cally significant drugs having a narrow therapeutic ratio such as terfenadine, astemizole, cisapride, warfarin, theophylline. Certain benzodiazepines anc phenytoin. Metabolized by hepatic oxidation (e.g Alprazolam, Midazolam, Trizolam etc.) Clearance of benzodiazepines metabolised by glucuronidase (e.g Lorazepam) oxazepam, Temazepam is unlikely to be effected by fluvoxamine. Diazepam: Generally not advisable. Propranolol and other betablockers Reduction in the initial beta-blocker dose Carbamazepine: - Increase toxicity, Lithium: - May enhance the serotonergic effects, Diltiazem : May lead to bradycardia.
DOSAGE: Adults: - The recommended starting dose 50mg per day as a single dose at bed time. The effective dose range is 100-300mg daily in divided doses, (50mg increments every 4-7 day's) maximum dosage 300mg/day. Children and adolescents Starting dose is 25mg per day (8-17 years) as a single dose at bed time. Effective dose range is 50 to 200mg per day, dose may be increased in 25mg increments every 4-7 days)