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Erythromycin is a macrolide antibiotic used topically alone or in combination with tretinoin for the treatment of inflammatory acne.

INDICATIONS: Papular inflammatory acne.

CONTRAINDICATIONS: Known hypersensitivity to erythromycin or its components, concomitant use with pimozide, terfenadine, astemizole or cisapride.

SAFETY PROFILE: Use with caution in patients with impaired renal or hepatic functions, G-6-PD deficiency. Do not contact with mucosal lining.

ADVERSE EFFECTS: Dryness, pruritus, erythema, desquamation, burning.

DRUG INTERACTIONS: Erythromycin decreases clearance of carbamazepine, cyclospore and triazolam. Decreases metabolism of terfenadine, cisapride, astemizole.

DOSAGE: Apply to affected area twice daily for 5-8 weeks.

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