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GALLAMIN PANCURONIUM ATRACURIUM : They act peripherally, not centrally and the site of action is neuromuscular junction where these competive blockers have affinity for the nicotinic (N2) cholinergic recptors at the muscle end-plate but have no intrisic activity ach released form motornerve endings is not able to combine with its receptors to gerate end-plate potential when the magnitude of EPP falls below a critical levels it is unable to trigger propagated muscle action ptential and muscle fails to contract in response ot nerve impulse.

Indications: Medium action non-depolarsing muscle relaxation in surgical anesthesia.

Contra Indication: Depressed respiration, inadequate general anesthesia Obstertics pior to delivery Hypersensitivity

Special Precautions: Myasthena gravis myopathy Deploarising drugs Poliomylites Severe cardiovascular disease Severe obsesity Renal unsuffclency Pregnacny typertension Hepatic disease Electroyte disturbances

Side effects: Bronchopasm flushing hypotension.